DISCOVER NESİLLER GENETİK

OUTSTANDING SERVICE
Nesiller Genetik makes it easier for its clients to manage their reference test needs with comprehensive testing possibility and experienced staff.
SCIENTIFIC EXPERIENCE
The core of Nesiller Genetik is our Research & Development department that operates to develop and perform special tests.
INNOVATION
By means of a continuing innovation tradition, Nesiller Genetik prioritise its clients’ needs with research, development, information technology and business support.
QUALITY ASSURANCE
Our quality criteria is a multi-staged scheme with the targets of continuous improvement and error-free process management. Nesiller Genetik provides long-term reliability and  required substructure in main reference laboratory as a genetic diagnosis center.

CLINICAL SERVICES

MEDICAL GENETIC CONSULTANCY
In our laboratory, we work to define families’ history of genetic diseases by diagnostics and physical examination and supportive genetic testing and genetic consultancy. Clinically acquired genetic diagnostic data is utilized for genetic consultancy sessions where diagnostics, treatment and outcomes are discussed. During these sessions, hereditary genetic conditions are disclosed and explained to our patients and their relatives.
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GENOMIC TUMOR CONSULTANCY
Cancer is a disease that can  originate from almost every organ and system in the body. Especially malignant tumors, while growing in the original tissues, also tend to spread into different organs in the body and become a systemic disease.

With this design, genomic tumor consultancy is an advice which is prepared for cancer patients, their relatives or individuals who are under the risk of developing cancer. During all this sessions, we work closely with Genomic Tumor Council. Especially in rare types, non-observant and  progressed cases, decisions for diagnosis, treatment and follow-ups are made in multi-diciplinary boards called tumor council in an inter-diciplinary way.

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CONSANGUINEOUS MARRIAGE CONSULTANCY
Consanguineous marriage is an important factor that affects genetic diseases’ epidemiology and consanguineous marriage rate is over 25% in Turkey. Hereditary diseases show up as a result of changes or mutations in heritage materials called genes. In these changed or mutated genes, the ones that cause a disease even when they are single dose are called dominant genes and the diseases are called dominant diseases. The other group is ressesive genes and cause a disease when they are double doses and the diseases  are called ressesive diseases. Disordered genes tend to come together more often in consanguineous marriages or closed societies, so in consanguineous marriages, ressesive hereditary diseases appear more frequently.
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HEALTHY LIVING | WELLNESS CONSULTANCY
In this type of consultancy, susceptibility to diseases and possible ways of prevention are determined by taking individuals’ genetic structure into consideration, scientific findings and suggestions about their life styles, nutrition and exercise habits. An individual’s health is the outcome of his/her genetic structure mixed with environmental factors.
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TERATOGENICITY CONSULTANCY
The word teratogen is used for matters that cause malformed, abnormal newborns. Even in developed countries, foetal malformed newborns are defined as products of fertiliy  and occur 2% of all the births. Teratogenicity is a condition that may occur in newborns as a result of using a teratogen matter.
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LABORATORIES SERVICES

Preimplantation Genetic Implementations are procedures that provide genetic disorders’ testing before the embryo is transferred to uterus, in other words before pregnancy starts and an embryo which is fertilised in lab conditions is examined.

Embryos could be genetically tested before being transferred to the couples who have history of hereditary disease in their families and who want to have a baby with in vitro fertilisation (IVF). In Nesiller Genetik labs, Preimplantation Genetic Diagnosis (PGD) procedure can be applied to all diseases which have molecular diagnoses. All PGD implementations are performed with molecular methods at Nesiller Genetik Laboratories. That can also be applied to reciprocal translocation and Robertsonian translocation carriers.

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Genetics is the cause of almost  10% of total infertility cases in couples.

Genetics in Male Infertility: The infertility cases usually consist (almost half of all the cases) of genetic related male infertility. Individuals who suffer from severe oligoasthenoteratospermia, obstructive azoospermia, nonobstructive azoospermia , oligoasthenoteratospermia and repetitive implantation failures carry risks in genetic aspects.

Y Chromosome Micro-Deletion: “azoospermia factor” in the long arm of Y chromosome or AZFa, AZFb and AZFc areas on “AZF” gene are related to male infertility.

Cystic Fibrosis Mutation: 1% to 2% of infertility in males is caused by congenital bilateral absence of the vas deferens (CBAVD). Genetic examination is applied to individuals who have cystic fibrosis or CBAVD diagnosed for cystic fibrosis transmembrane regulator (CFTR) gene mutations.

Genetics in Female Infertility: Genetic abnormalities in females can cause infertility by affecting reproduction cycle and/or hormone balance. These genetic findings include chromosomal irregularities and single-gene mutations. The most common cause of female infertility is chromosomal abnormalities and mutations in FMR1 gene in X chromosome which is responsible for Fragile X syndrome.

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Peripheral blood and tissue samples are used for postnatal diagnosis. Chromosomes obtained from these samples are examined by numbers and structure. While micro-deletion or reorganizing examinations are held in babies who got clinical diagnosis for a syndrome or who got defects/faults dysmorphologically, in adults, these examinations are usually performed for infertility. Additionally, mutation scanning is also performed on these samples.

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Prenatal diagnosis is examining the samples including genes or chromosomes belonging to foetus before birth. For prenatal diagnosis, samples belonging to foetus are obtained by invasive methods.

Chorionic villus biopsy (CVS) is one of these methods and in this method, sampling is made from intra uterine face of placenta  in the 10th week of pregnancy for genetic examination.

Same examination could be made by another method called Amniocenteses (AS) in the 16th week of pregnancy. Amniocenteses (AS) is sampling from the liquid that contains the  foetus.

It is possible to perform another examination called Cordocenteses (CS) after the 20th week of pregnancy or if there are doubts about earlier examinations. Cordocenteses is sampling from foetus’ cordon blood and making genetic examinations on foetal blood.

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Non-invasive prenatal testing (NIPT) is a method developed for scanning chromosomal abnormalities and single-gene diseases with extracellular foetal DNA. In this method, ‘sample belonging to foetus’ is obtained from maternal blood, not from placenta or amniotic fluid which requires an in-vasive procedure. In 2011, NIPT for chromosomal abnormalities was performed for the first time in USA, West Europe and China.

In NIPT, by obtaining foetus’ DNA by 10cc maternal blood, numeric and structural abnormalities in all chromosomes can be scanned in additon to detection of Trisomia 21 (Down Syndrome), Trisomia 18 (Edwards Syndrome) or Trisomia 13 (Patau Syndrome). In our laboratories, chromosomal abnormalities are examined with number of chromosomes that foetus have and in addition, Rh determination can be made starting from the 6th week of pregnancy.

Whole Genome NIPT for prenatal diagnosis of chromosomal abnormalities represents an advanced scanning instrument and enables detection of clinically important imbalances which can’t be determined by using conventional NIPT. This scanning level presents a higher accuracy, an importantly higher sensitivity when compared to standard scanning and have a potential to enhance extensive pregnancy management. (Francesco Fiorentino*).

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paternity testing

In paternity testing,  we compare DNA areas which should be matching both in the child and in the father. If these areas match, father candidate is the biological father of the child but if they don’t, father candidate is not the biological father. In our laboratories, STR based paternity tests are performed based on biological samples (vinous blood, saliva, barba et al) from children and father candidates. For ethical reasons, this test is not performed on foetus (CVS, amniotic liquid, cord blood)

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Cancer is a disease caused by uncontrolled divison and propagation to nearby/far tissues of cells with damaged or mutated DNA. These cells can’t execute apoptosis (planned death of cells) process because of DNA damage. The cells which divide and increase in number in an uncontrolled way become masses and form the tissue called tumor.

Cancer originates from DNA damage or mutation that is why it is considered as a genetic disease. But if these masses (formed of uncontrollably increasing cells) do not spread to other tissues or organs, the mass is called a benign tumor. But if it is spread into nearby tissues or into different area/s of the body, this is called malignant tumor; in other words cancer.

There are 2 main factors causing cancer; hereditary factors and environmental factors. A genetic change is a necessary component for cancer and these genetic changes usually caused by environmental factors. As it is mentioned in the web-site of Genomic Tumor Council, in limited number of cases (approximately 10%), cancer may be inherited from the mother or father.

Scannings, definitive diagnosis tests, tumor profiling tests, liquid biopsy, hereditary cancer tests are widely used to diagnose cancer.

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Hematology is a field of medicine that examines conditions related to bone marrow, lymphatic system and blood. Hematology tests performed in our laboratories diagnose several diseases such as; anemia, leukemia, multiple mylema etc.

In our laboratory we have conventional as well as state of the art technology for molecular diagnosis of various hematological benign and malignant diseases. Thanks to this substructure, we provide various testing options and high-standard clinical and scientific guidance.

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DNA sequencing, which means determination of sequencing of DNA building blocks (nucleotides) belonging to an individual’s genetic code helped genetics studies to advance and has become a technique that is  used for testing genetic abnormalities.

To determine genetic variations, Whole Exome Sequencing (WES) and Whole Genome Sequencing (WGS) methods are now more often used in areas of health and related researches. Both methods based on new technologies called New Generation Sequencing (NGS) that provides rapid sequencing of large amounts of DNA.

With the “Human Genome Project”, we now know that human genome is coded with 3 billions of DNA and composed of 20.000 – 25.000 genes that synthesize proteins. A more interactive relationship has been established between genetics and medicine.

We can help you improve your quality of life  by using this interactive relation.To access more info about our services under the title of “Healthy Gene”, please visit www.saglikligen.com web site.

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Phamacogenetics mean the interaction of medicine with one’s genetic structure. Pharmacogenetic tests provide genetic information about patient’s age, weight, existing conditions, current medication, general health and lifestyle. The results help doctors to choose “the best medication in suitable dose”.

In our laboratory, we perform several pharmacogenetic tests. We can help you in pharmacogenetics to detect the interaction of medication you use, it’s effect to your metabolism, the reaction of your genetic structure to this medication and we can develop a tailor-made treatment (suitable for your metabolism and genetic structure) for you in coordination with your doctor.

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Molecular genetic analysis in cardiology helps detecting some characteristic changes related to cardiac defect types and sub-types. As an example, variations in MYH7 and MYBPC3 genes indicate to Hypertrophic  Cardiomyopathy (HCM). Besides, molecular cardiology genetic practices are used in sports genetics, too.

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Nesiller Genetik Diagnosis Center provides you healthy styles by using its wellness, nutrigenetics and genetics of sports tests. Nutrigenetics is a field of science that studies the genetic structure effecting nutriments’ metabolism and examines nutriments and genetic interactions by genotypes. Malnutrition (lack or excess of nutrition) directly affects gene expression and genome stability. Once somebody’s tendency to put on weight and sensitivity for weight-loss interventions is established,  the results should be reviewed at molecular and metabolic levels.

In genetics of sports, tests applied to your physical activites can help determine the causes of injuries. Soft tissue injuries including tendons and ligaments are commonly seen in recreational and competitive athletes. Athletes have inherent risk for these acute injuries which include a genetic component and they get injured after exposure to external factors and traumatisation.  For example, in several studies, genetic factors are proven to be related to risk of Achilles tendinopathy.

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Genetic counseling provides you with the latest, accurate and detailed information about genetic diseases that are likely to be transferred from your family to your children.
Monday – Friday  09.00 – 18.00 | Saturday 09.00 – 14.00